Scientific Publications
Publications of the IWG TTP
Scientific publications developed through international collaboration among members of the International Working Group on TTP, including consensus work and collaborative original research.
Original Research
Collaborative research from the IWG TTP
The Capla 1000+ project represents the first published original research project developed as an initiative of the International Working Group on TTP.
Caplacizumab use in immune-mediated thrombotic thrombocytopenic purpura: an international multicentre retrospective cohort study (The Capla 1000+ project)
eClinicalMedicine. 2025;82:103168.
This international multicentre study evaluated outcomes among 1,015 patients with immune-mediated TTP treated with caplacizumab in combination with therapeutic plasma exchange and immunosuppression and compared them with 510 historical controls. The study provides evidence supporting early caplacizumab use during acute iTTP and demonstrates the value of international collaboration in studying outcomes in this rare disease.
Consensus Publications
Building a common language for TTP
International consensus work has helped establish shared terminology and outcome definitions as the diagnosis, monitoring, and treatment of TTP continue to evolve.
Consensus on the standardization of terminology in thrombotic thrombocytopenic purpura and related thrombotic microangiopathies
Journal of Thrombosis and Haemostasis. 2017;15:312–322.
International Working Group consensus addressing terminology for the classification, diagnosis, monitoring, treatment response, and outcomes of TTP and related thrombotic microangiopathies.
Redefining outcomes in immune TTP: an international working group consensus report
Blood. 2021;137:1855–1861.
This international consensus report updated outcome definitions in immune TTP to incorporate ADAMTS13 activity and the effects of anti-VWF therapy into modern response and relapse terminology.
Continuing Collaboration
Advancing the TTP evidence base
Additional publications resulting from IWG TTP collaborative research, consensus initiatives, scientific meetings, and working groups will be added as they are published.